Evangelical Protestant groups predominate in Oklahoma with adherents representing about 41.4% of the total population in 2000.

The leading Protestant group in 2000 was the Southern Baptist Convention with 967,223 adherents. Other leading Evangelical Protestant denominations include the Assemblies of God, 88,301 adherents; the Churches of Christ, 83,047; the Christian Church (Disciples of Christ), 53,729; and the Christian Churches, 42,708. The largest Mainline Protestant denominations are the United Methodist Church, with 322,794 adherents, and the Presbyterian Church USA, with 35,211 adherents. In 2000, there were 168,625 Roman Catholics, 6,145 Muslims, and about 5,050 Jews throughout the state. About 39.2% of the population did not claim any religious affiliation.